350D + 24-105mm f/4 L IS USM Combination?

Hi Everyone,
I have recently been looking at upgrading my current lens (Tamron AF 18-200mm XR Di II) to the 24-105mm f/4 L IS USM lens.
I had the opportunity today to actually try the lens on at the shop onto my 350D body (wow it seemed like a serious pro lens and it felt so good in my hands
).
There is a considerable size difference from my current lens and I am wondering if this would cause any issues? (I know it sounds like a silly question...)
Also does anyone have this combo that they are using? Hopefully sometime down the line, I will be upgrading to a better body (fingers crossed).
I have read heaps of reviews on this lens and I plan to mainly take portraits and landscape shots, so I thought this would be ideal lens.
Everyone's thoughts??
I have recently been looking at upgrading my current lens (Tamron AF 18-200mm XR Di II) to the 24-105mm f/4 L IS USM lens.
I had the opportunity today to actually try the lens on at the shop onto my 350D body (wow it seemed like a serious pro lens and it felt so good in my hands

There is a considerable size difference from my current lens and I am wondering if this would cause any issues? (I know it sounds like a silly question...)
Also does anyone have this combo that they are using? Hopefully sometime down the line, I will be upgrading to a better body (fingers crossed).
I have read heaps of reviews on this lens and I plan to mainly take portraits and landscape shots, so I thought this would be ideal lens.
Everyone's thoughts??